12/12/2023 0 Comments Compare foods st marks![]() For four dyes where adequate dose-response data from animal and human studies were available, comparisons of the effective doses in studies that measured behavioral or brain effects following exposure to synthetic food dyes indicate that the basis of the ADIs may not be adequate to protect neurobehavior in susceptible children. ![]() The current Food and Drug Administration (FDA) acceptable daily intakes are based on older studies that were not designed to assess the types of behavioral effects observed in children. Together, the human clinical trials and animal toxicology literature support an association between synthetic food dyes and behavioral impacts in children. Animal toxicology literature provides additional support for effects on behavior. These studies support a relationship between food dye exposure and adverse behavioral outcomes in children. Sixteen (64%) out of 25 challenge studies identified some evidence of a positive association, and in 13 (52%) the association was statistically significant. ![]() All studies used a cross-over design and most were double blinded and the cross-over design was randomized. We identified 27 clinical trials of children exposed to synthetic food dyes in this review, of which 25 were challenge studies. Finally, we conducted a hazard characterization of the potential neurobehavioral impacts of food dye consumption. We also conducted a search of the animal toxicology literature to identify studies of neurobehavioral effects in laboratory animals exposed to synthetic food dyes. OEHHA conducted a systematic review of the epidemiologic research on synthetic food dyes and neurobehavioral outcomes in children with or without identified behavioral disorders (particularly attention and activity). Concern that synthetic food dyes may impact behavior in children prompted a review by the California Office of Environmental Health Hazard Assessment (OEHHA).
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